Manufacturer: DUPHAR manufactures COLOSPA.


The uses of COLOSPA include:
Category : Antispasmodic; smooth muscle relaxant.

Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:

- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes

- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine

- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings