When oral therapy is required in the treatment of mild to moderately severe infections due to penicillin sensitive organisms. Therapy should be guided by bacteriological studies, including sensitivity tests, and by clinical response.
For prophylactic use in recurrent streptococcal infections including the prevention of recurrence following rheumatic fever and/or Sydenham's chorea and to prevent bacterial endocarditis in patients with rheumatic fever and/or congenital heart disease who are about to undergo dental or upper respiratory surgery or instrumentation.
Note: Oral penicillin should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower intestinal tract surgery, sigmoidoscopy or complications of childbirth.
Dosage and Administration:
250mg to 500mg every four to six hours, preferably one hour before food. The dosage should be determined according to sensitivity of the organisms and severity of the infection.
Prevention of recurrence following rheumatic fever: 250mg twice a day continuously.