Manufacturer: Rhone-Poulenc Rorer manufactures Frumil.
The uses of Frumil include:
Frumil tablets and Frumil LS tablets contain two active ingredients, amiloride hydrochloride and furosemide. Furosemide is a type of medicine called a loop diuretic, and amiloride is a type of medicine called a potassium-sparing diuretic. This combination of diuretics is also known as co-amilofruse. (NB. Co-amilofruse tablets are also available without a brand name, ie as the generic medicine.)
Diuretics are sometimes referred to as ‘water tablets’. They remove excess fluid from the body by increasing the production of urine.
Diuretics act in the kidneys. They work by causing the kidneys to increase the amount of salts, such as potassium and sodium, that are filtered out of the blood and into the urine. When these salts are filtered out of the blood by the kidneys, they draw water alongside them. As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood and into the urine.
Loop diuretics like furosemide are strong diuretics that cause lots of potassium to be filtered out of the blood. This can sometimes cause the level of potassium in the blood to fall too low. A low blood potassium level is called hypokalaemia and can sometimes be dangerous, particularly for people with heart disease or liver disease.
Amiloride on the other hand, is a weaker diuretic that causes potassium to be retained in the body. It is used in combination with furosemide to prevent the amount of potassium in the blood from falling too low.
Co-amilofruse is used to treat conditions where excess fluid has been retained in the body (oedema) and where a drop in the amount of potassium in the blood could be dangerous.
For example, it is used in heart failure, where the pumping mechanism of the heart is less effective. This can cause fluid to build up in the ankles, causing swollen ankles, and in the lungs (pulmonary oedema), which makes it difficult to breathe. Furosemide helps the body to remove this excess fluid. Removing fluid from the blood vessels also decreases the pressure within the blood vessels. This makes it easier for a weak heart to pump blood around the body.
It is also used to remove excess fluid that can accumulate as a result of cirrhosis of the liver. This fluid may accumulate and cause swelling in the abdomen (ascites) or in the legs (peripheral oedema).
What is it used for?
Treating fluid retention (oedema) in conditions where it is important that the amount of potassium in the blood does not fall too low, for example in heart failure, liver cirrhosis, kidney disease, or oedema caused by treatment with corticosteroids or oestrogens.