Manufacturer: Sanofi Aventis manufactures Largactil.

Uses:

The uses of Largactil include:
LARGACTIL is indicated in the following conditions:

1.Schizophrenia and other psychoses (especially paranoid),

mania and hypomania.

2.In anxiety psychomotor agitation excitement, violent or

dangerously impulsive behaviour. LARGACTIL is used as an

adjunct in the short-term management of these conditions.

3.Intractable hiccup.

4.Nausea and vomiting of terminal illness (where other

medicines have failed or are not available).

5.Induction of hypothermia is facilitated by LARGACTIL which

prevents shivering and causes vasodilation.

6.Childhood schizophrenia and autism.

Dosage and Administration

Oral administration should be used whenever possible. Dosages should be low to begin with and gradually increase under close supervision until the optimum dosage within the recommended range for the individual is reached. Individuals vary considerably and the optimum dose may be affected by the formulation used.

The parenteral formulation may be used in emergencies. It may only be administered by deep intramuscular injection. LARGACTIL is too irritant to give subcutaneously. Repeated injections should be avoided if possible.

Schizophrenia, Psychoses, Anxiety and Agitation

Oral

Adult

Initially 25 mg three times daily or 75 mg at bedtime increasing by daily amounts of 25 mg to an effective maintenance dose. This is usually in the range 75 to 300 mg daily, but some patients may require up to 1 g daily.

Children

Under 1 Year: Do not use unless need is life saving.

1-5 Years: 0.5 mg/kg bodyweight every 4 - 6 hours to a maximum recommended dose of 40 mg daily.

6 -12 Years: A third to half the adult dose, to a maximum recommended dose of 75 mg daily.

Elderly

Start with a third to a half the usual adult dose with a more gradual increase in dosage.

Intramuscular

Adult

For acute relief of symptoms 25 - 50 mg every 6 - 8hours.

Children

Under 1 Year: Do not use unless need is life saving.

1-5 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Dosage is not advised to exceed 40 mg daily.

6-12 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Not to exceed 75 mg daily.

Elderly

Doses in the lower range for adults should be sufficient to control symptoms, i.e. 25 mg, 8 hourly.

Intractable Hiccup

Oral

Adult

25 - 50 mg three or four times daily.

Children

No information available.

Elderly

No information available.

Intramuscular

Adult

25 - 50 mg every 6-8 hours. .

Children

No information available.

Elderly

No information available

Intravenous Infusion

Adult

If other routes of administration are inappropriate, give 25-50 mg in 500-1000 ml sodium chloride by slow intravenous infusion every 6-8 hours.

Children

No information available.

Elderly

No information available.

Induction of hypothermia to prevent shivering

Intramuscular

Adult

25 - 50 mg every 6 - 8 hours.

Children

Under 1 Year: Do not use in children this age.

1-12 Years: Initial dose: 0.5 - 1.0 mg/kg. Maintenance: 0.5 mg/kg every 4 - 6 hours.

Elderly

No information available.

Nausea and Vomiting of Terminal Illness

Oral

Adults

10 - 25 mg every 4 - 6 hours.

Children

Under 1 Year: Do not use unless need is life saving.

1-5 Years; 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 40 mg.

6 - 12 Years: 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 75 mg.

Elderly

Initially a third to half the adult dose. The physician should then use their clinical judgement to obtain control.

Intramuscular

Adults

25 mg initially, then 25 - 50 mg every 3 - 4 hours until vomiting stops, then drug to be taken orally.

Children

Under 1 Year: Do not use unless need is life saving.

1 - 5 Years: 0.5 mg/kg 6 - 8 hourly. It is advised that maximum daily dosage should not exceed 40 mg.

6-12 Years: 0.5 mg/kg every 6 - 8 hours. It is advised that maximum daily dosage should not exceed 75 mg.

Elderly

For oral use only.