Management of essential hypertension. It may be tried as a sole therapeutic agent in the treatment of mild to moderate hypertension. Normally Indapamide is used as the initial agent in multiple drug regimes.
Dosage and Administration
Adults. 1 tablet (2.5 mg indapamide) daily to be taken in the morning. The action of Indapamide is progressive and whilst the optimum reduction in blood pressure is usually seen after four weeks, a further small but useful reduction in blood pressure may be observed over the following four to six weeks. A larger dose than 1 tablet (2.5 mg) of Indapamide daily is not recommended as there is little additional antihypertensive effect, whilst the diuretic effect becomes more prominent.
A single daily tablet of Indapamide may effectively be combined with the following antihypertensive agents: beta-blockers, methyldopa, clonidine, prazosin, and ACE inhibitors. Although it is recommended that patients be monitored closely in the initial stages.
Combination with a diuretic agent is not recommended as significant electrolyte disturbances may ensue. Indapamide has a slight but significant carry-over hypotensive effect lasting up to 1 or 2 weeks after the cessation of therapy.