Manufacturer: Roche NZ Ltd manufactures Naprosyn SR.

Uses:

The uses of Naprosyn SR include:
Naprosyn SR tablets are indicated for its anti-inflammatory and analgesic action in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and other musculoskeletal disorders.

Naprosyn tablets and suspension are indicated for its anti-inflammatory and analgesic action in the treatment of rheumatoid arthritis, osteoarthritis (degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid arthritis, acute gout, acute musculoskeletal disorders, post-operative pain and dysmenorrhoea.

Dosage:

Adults

For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis

Initial therapy

The usual dose is 500-1000 mg per day taken in two doses at 12 hour intervals. The tablets should be swallowed whole with liquid preferably after meals. Where 1000 mg per day is needed, the suggested regimen is one Naprosyn 500 mg tablet twice daily.

Maintenance treatment

The maintenance dose is usually 500 mg per day taken in two doses at 12 hour intervals, i.e. 250 mg on awakening and 250 mg before retiring. The tablets should be swallowed whole with liquid preferably after meals. Dosage adjustments within the range of 500-1000 mg per day, maintaining 12 hour interval administration, may be employed. The size of the morning and evening doses should be adjusted on the basis of predominant symptoms, i.e. night time pain or morning stiffness.

Alternatively, patients stabilised on a daily maintenance dose of 500 mg, 750 mg or 1000 mg may administer their daily requirements as a single dose as naproxen has been shown to be effective when administered as a single daily dose. For convenience, patients stabilised on a daily maintenance dose of 750 mg or 1000 mg naproxen may administer their daily requirements by using the corresponding Naprosyn SR tablet at night with food or milk. The Naprosyn SR tablets must not be chewed or broken.

The total daily dose of naproxen should not exceed 1000 mg maintaining 12 hour interval administration.

For acute gout

750 mg should be given initially, followed in 8 hours with 500 mg, and thereafter 250 mg at 8 hour intervals until the attack has passed.

For dysmenorrhoea

500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for up to 5 days, if necessary.

For adult usage in other indications (analgesia and acute muscular skeletal disorders)

500 mg should be given initially, followed by 250 mg at 6-8 hour intervals, if necessary.

Children

For juvenile rheumatoid arthritis

The usual dose for children over 5 years is 10 mg/kg/day given as two divided doses at 12 hour intervals. Therapy in children under 5 years of age is not recommended.

Naprosyn EC (enteric coated) tablets

Adults

For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis

Initial therapy

The usual dose is 500mg to 1000mg per day taken in two doses at 12 hour intervals. The tablets should be swallowed whole with liquid, preferably after meals.

Maintenance treatment

The maintenance dose is usually 500mg per day taken in two doses at 12-hour intervals. Dosage adjustments within the range of 500 to 1000mg per day, maintaining 12-hour interval administration, may be employed. The size of the morning and evening doses should be adjusted on the basis of predominant symptoms, i.e. night-time pain or morning stiffness.

The total daily dose of naproxen should not exceed 1000mg.

Children

The safety of Naprosyn EC for paediatric use has not been established.

Naprosyn Suspension

Shake the suspension gently before use.

Adults

Dosage is the same as that for Naprosyn tablets and Naprosyn SR tablets. The adult dose of 500-1000mg tablets per day is equivalent to 10-20 mL twice daily of Naprosyn Suspension.

Children

The usual dose for children over 5 years is 10 mg/kg/day given as two divided doses at 12 hour intervals. Therapy in children under 5 years of age is not recommended.